https://openjournals.ljmu.ac.uk/BRR <p>Biomolecular Research Reports (BRR) aim to stimulate and promote original and interdisciplinary research by actively engaging the research community through timely and relevant publications. <br>BRR will publish three types of articles.</p> <ul> <li class="show"><strong>Perspectives &amp; Commentaries. </strong>These articles will provide insightful analyses of developments in a specific biomolecular research area. Contributions may also present global views or a potential paradigm shift in a specific or broad research area. The Editorial Board will invite authors for submissions to this category.</li> <li class="show"><strong>Reviews</strong> will present concise appraisal and synthesis of the latest developments on a specific research topic. Authors are expected to have relevant research expertise on the review topic evidenced by publications track record or active research programme in the field.</li> <li class="show"><strong>Research Papers</strong> will present findings from original work with writing styles and formats that emphasise rationale, design, findings, and implications. Priority will be placed on soundness of scientific methods as reflected in the design of experiments, reproducibility and balanced interpretation of data. The goal is not to select papers for publication based on their perceived current scientific impact</li> </ul> <p>We invite submissions to the Commentaries &amp; Perspectives, Reviews, and Research Papers sections of the journal across a wide range of research fields with elements of the biomolecular sciences as the subject of investigation or as research tools in related areas. These include but not limited to biochemistry, biophysics, molecular biology, biotechnology, microbiology, biomedical sciences, chemical biology, pharmacology, natural product chemistry, environmental chemistry, and forensic biosciences. The Editorial Board are particularly interested in contributions that incorporate an interdisciplinary approach to experimental science.</p> Liverpool John Moores University en-US Biomolecular Research Reports <p>This journal provides immediate open access to its content with no submission or publications fees. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a <a href="http://creativecommons.org/licenses/by/4.0" target="_blank" rel="noopener">&nbsp;Licence</a><a href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</a> that allows others to read, download, copy, distribute,&nbsp; print, search, or link to the full text of works in this journal. It also allows others to remix, adapt and build upon the work, as long as credit is given to the author(s).&nbsp;&nbsp;</p> https://openjournals.ljmu.ac.uk/BRR/article/view/2557 <p>Medulloblastoma is a paediatric brain cancer categorised into various subtypes that have differing prognostic outcomes<br>for patients. As with other cancers, microRNAs have been implicated in medulloblastoma pathogenesis and<br>the loss of specific miRNAs appears to contribute to the disease. There is therefore an urgent need to develop<br>miRNA-replacement therapies for medulloblastoma. However, methods for targeted delivery of small RNAs to medulloblastoma<br>cells have not been fully established. As a step towards tackling this challenge, we have developed<br>self-assembling peptide nanoparticles for small RNA delivery to medulloblastoma cells. We generated an amphiphilic<br>peptide, TY-28, using solid-phase peptide synthesis and combined TY-28 with miR-124-3p. Analysis of the resulting<br>complexes by electron microscopy and dynamic light scattering confirmed the formation of nanoparticles. The ability<br>of the NPs to penetrate cells was monitored by labelling the miRNA with a fluorescent dye. The NP:miRNA complexes<br>were readily internalised by group 3 medulloblastoma cells, and the accumulation of the complexes increased over<br>time. Levels of uptake were 6-fold higher at 24 hours compared to 4 hours in serum-free medium. The uptake of the<br>NPs complexes by the cells did not differ in the presence and absence of serum, suggesting the presence of serum<br>did not affect complex stability. Our findings point to the translational potential of self-assembled NPs to delivery miRNA<br>mimics to medulloblastoma cells.</p> Ellie Harland Dima Alhusban Roush Abdoubaki Dallas Marfing Alan Simm Alice McCloskey Touraj Ehtezazi Kehinde Ross Copyright (c) 2023 Ellie Harland, Dima Alhusban, Roush Abdoubaki, Dallas Marfing, Alan Simm, Alice McCloskey, Touraj Ehtezazi, Kehinde Ross https://creativecommons.org/licenses/by/4.0 2023-12-31 2023-12-31